NMN是人体固有的物质
    自从哈佛医学院的研究发现NMN可以逆转衰老,绕让60岁的小鼠身体指标回到20岁的状态,NMN开始被称为“长生不老药“。事实上这种物质是人体固有的,NMN是烟酰胺单核苷酸Nicotinamide mononucleotide的简称 是NAD+的前体,参与上千种人体的生化反应,是人体重要的辅酶。详情阅读》
NMN是补充NMN最直接的方式

氨酸、烟酸、烟酰胺和NMN/NR四种物质可以补充NAD+,色氨酸/烟酸/烟酰胺无法绕过NAMPT酶的限制,NR在胃中会被消化,NMN是补充NAD+最有效的途径:


A,通过消化系统完好无损地吸收;

B,2~3分钟进入血液;

C,15分钟内提升组织中的NMN含量;

D,迅速提升血液、肝脏等器官中的NAD+水平

NMN在体内的吸收非常迅速,可以迅速提高体内NAD+水平(如右图):详细阅读》

口服NMN后NMN和NAD+浓度曲线


食物类型
名称
Mg/100g食物
蔬菜
毛豆
0.47–1.88
蔬菜
西兰花
0.25–1.12
蔬菜
黄瓜种子
0.56
黄瓜
0.65
蔬菜
卷心菜
0.0–0.90
水果
鳄梨
0.36–1.60
水果
番茄
0.26–0.30
菌类
蘑菇
0.0–1.01
牛肉(生)
0.06–0.42
海鲜
0.22



     根据FDA的等效原则,一个70Kg的成年人每天应补充600mg的NMN。NMN在食物中富含较多,NMN含量如下表,一个成年人补充同等量的600mg/天的NMN,则需要吃掉32~128kg的毛豆,或者54~240kg的西兰花。而且这还是在保证完全吸收的情况下,这显然是不现实的,补充非食物来源的NMN显得尤为重要。

备注: NMN通过高压液相测定

来源:Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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NAD+随年龄增长降低
NAD+三个代谢途径
       随着年龄增长,NAD+在体内含量降低,衰老随之而至(见右图)。NAD+在三个独立的代谢途径下保持平衡(见左图),其中补救合成途径占到了NAD+生成量的85%,详细了解》

NMN对人体健康有重要作用
      人体95%的能量都来自三羧酸循环,NAD+是三羧酸的辅酶,NMN作为NAD+的前体可显著提高精力。除此之外NMN还能对人的健康能产生重要影响,NAD+作为PARPcADPRSirtuins三种酶的唯一底物,对延长寿命有重要作用。作为上千种生化反应的辅酶,对还对神经退行性疾病(老年痴呆、帕金森、)、II糖尿病、运动能力、DNA修复有重要影响。详细阅读》
NAD+有三个独立的代谢途径
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